ISSN 1662-4009 (online)

ey0018.15-13 | (1) | ESPEYB18

15.13. Socioeconomic status is related to pubertal development in a German cohort

L Oelkers , M Vogel , A Kalenda , HC Surup , A Korner , J Kratzsch , W Kiess

Hormone Research in Paediatrics 2020;93:548–557https://bit.ly/2ToJvmvThe authors studied 2,657 German children aged 5-18 years to look for social patterning in the age at puberty timing and circulating gonadotrophin levels. Lower socio-economic status (SES) was associated with earlier thelarche, longer duration of puberty, and overweight in girls, but not age at menarche. In boys, lower SES showed a tren...

ey0019.11-4 | New findings in adipose tissue biology | ESPEYB19

11.4. Expression of the adipocyte progenitor markers MSCA1 and CD36 is associated with adipose tissue function in children

M Hanschkow , N Boulet , E Kempf , A Bouloumie , W Kiess , R Stein , A Korner , K Landgraf

kathrin.landgraf@medizin.uni-leipzig.de JCEM 2022; 107(2): e836–e851https://pubmed.ncbi.nlm.nih.gov/34448000Brief Summary: This study investigated the association of the novel adipose-derived stem cell (ASC) markers Mesenchymal Stem cell Antigen 1 (MSCA1) and CD36 with adipose tissue function in samples collected from children...

ey0016.11-5 | Tracking, Programming, and Epigenetics | ESPEYB16

11.5. Acceleration of BMI in early childhood and risk of sustained obesity

M Geserick , M Vogel , R Gausche , T Lipek , U Spielau , E Keller , R Pfaffle , W Kiess , A Korner

To read the full abstract: N Engl J Med. 2018;379(14):1303–1312.This analysis of longitudinal BMI data from early childhood to adolescents in 51,505 German subjects (CrescNet patient registry) allows a new insight into BMI development, specific dynamics and BMI trajectories from childhood to early adulthood.The exact pattern and time course of weight gain duri...

ey0020.2-6 | Important for Clinical Practice | ESPEYB20

2.6. Growth patterns of children with short stature in adulthood according to auxological status and maturity at birth

R Pfaffle , M Knupfer , M Gobert , M Vogel , R Gausche , C Beger , E Keller , A Korner , U Thome , W Kiess

Brief summary: This retrospective longitudinal study included 5698 patients with multiple height measurements since birth to the near-adult age. The aim was to define different growth patterns of children from birth to 18 years corrected for gestational age, sex and auxological status at birth in order to early identify children at risk for adult short stature. Adult height was significantly reduced in preterm and/or in small-for-gestational-age (SGA) children, with no sex dif...

ey0018.4-6 | Growth Hormone Therapy: Safety | ESPEYB18

4.6. Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study

L Savendahl , R Cooke , A Tidblad , D Beckers , G Butler , S Cianfarani , P Clayton , J Coste , ACS Hokken-Koelega , W Kiess , CE Kuehni , K Albertsson-Wikland , A Deodati , E Ecosse , R Gausche , C Giacomozzi , D Konrad , F Landier , R Pfaeffle , G Sommer , M Thomas , S Tollerfield , GRJ Zandwijken , JC Carel , AJ Swerdlow

Lancet Diabetes Endocrinol. 2020;8(8):683–692. doi: 10.1016/S2213-8587(20)30163-7. PMID: 32707116SAGhE is a large independent European consortium including eight different countries (Belgium, France, Germany, Italy, The Netherlands, Sweden, Switzerland, and the UK) which was set up to evaluate the long-term safety of rhGH in a large cohort (>24 000) of young adult patients t...